Albendazole Syrup 400mg / 10ml Treatment of Giardia Oral Suspension Drugs

Albendazole For Oral Suspension Drugs 400mg/10ml 1 Bootle / Box

Albendazole Syrup Drugs 400mg/10ml

COMPOSITION:

Each 10 ML syrup contains:400 mg of Albendazole.

PHARMACOLOGICAL ACTION:

Albendazole is a benzimidazole carbamate with anthelmintic and antiprotozoal activity against intestinal and tissue parasites. Animal studies have shown that albendazole exhibits vermicidal, ovacidal and larvacidal activity and exerts its anthelmintic effect by inhibiting tubulin polymerization. This causes the disruption of the helminth metabolism, including energy depletion, which immobilises and then kills the susceptible helminth. In man, after oral administration, albendazole is absorbed and completely metabolized. At a dose of 6,6 mg/kg of albendazole the plasma concentration of its main metabolite, the sulfoxide, attains a maximum of 0,25 to 0,30 micrograms/mL after approximately 2½ hours. The half-life of the sulfoxide in the plasma is 8% hours. The metabolite is essentially eliminated via the urine.

INDICATIONS:

Albendazole is indicated in the treatment of single or mixed intestinal parasites. Clinical studies have shown albeneffective in the treatment of Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm/threadworm), Ancylostoma duodenale and Necator americanus (hookworm), Taenia spp. (tapeworm) and Strongyloidesstercoralis.
Albendazole has been shown to be effective in the treatment of Giardia (duodenalis or intestinalis or lamblia) infections in children.

CONTRA-INDICATIONS:

Albendazole is known to be teratogenic and embryotoxic in animals. The safety of albendazole during pregnancy has not been established, and Albendazole should not be taken by pregnant women at any stage of their pregnancy or by women who are likely to become pregnant, during or shortly after the course of therapy. Albendazole is contra-indicated in patients with a known history of hypersensitivity to albendazole or constituents.

DOSAGE AND DIRECTIONS FOR USE:

Usual Dose:
10 mL (400 mg) of Albendazole Syrup suspension as a single dose in both adults and children over two years of age. The usual dose in children between one and two years of age is 5 mL (200 mg) of Albendazole Syrup suspension as a single dose. In heavy mixed infestation involving Strongyloides or Taeniasis, a single daily dose may be inadequate and the dose may be given for three consecutive days.
Note:
If the patient is not cured after three weeks, a second course of treatment may be given. No special procedures, such as fasting or purging, are required.
Albendazole has not been adequately studied in children under one year of age.
Giardiasis (dose in children over 2 years of age):
A single 400 mg daily dose (10 mL suspension) for five days.
The tablets may be chewed, swallowed or crushed and they should be taken with food.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:

Gastrointestinal discomfort, diarrhoea, headache and dizziness have been reported.
Hypersensitivity reactions including rash. pruritus and urticaria have been reported less frequently. 

Interactions:
Praziquantel has been reported to increase the plasma levels of the albendazole active metabolite.

STORAGE INSTRUCTIONS:
Store in a cool place (below 25°C). Protect suspension from light.
KEEP OUT OF REACH OF CHILDREN.