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|Product Name:||Vitamin B12 Injection||Composition:||Each 2ML Injection Contains:Vitamin B12 1MG|
|Indications:||Indicated In Vitamin B12 Deficiencies||Urogenital Trichomoniasis,Amoebiasis,Ulcerative Gingivitis, Infections Caused By Anaerobic Bacteria,:||Store Below 25°C. Protect From Light.|
|Expiration Date:||3 Years|
VITAMIN B12 INJECTION
Each 2 mL contains: 1000 micrograms (1 mg) Cyanocobalamin
Cyanocobalamin is involved by way of its participation in the formation and metabolism of purines and pyrimidines, in the synthesis of nucleoproteins, and thus in the maintenance of normal haemopoiesis.
Vitamin B12 substances bind to intrinsic factor and are then actively absorbed from the gastro-intestinal tract. Absorption is impaired in patients with an absence of intrinsic factor. Absorption from the gastro-intestinal tract can also occur by passive diffusion. Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. It is stored in the liver, excreted in the bile and undergoes extensive enterohepatic recycling; part of an administered dose is excreted in the urine, most of it in the first 8 hours; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. Vitamin B12 diffuses across the placenta and also appears in breast milk.
Indicated in vitamin B12 deficiencies manifested by megaloblastic anaemia and neurological conditions. Pernicious anaemia and its neurological complication, subacute combined degeneration of the spinal cord. Macrocytic anaemias associated with nutritional deficiencies. Intestinal malabsorption, megaloblastosis, diet-related deficiency, post-gastrectomy. Indications for prophylaxis include strict vegetarianism, post-gastrectomy, and ileal resection and conditions of the small intestine that would predictably cause deficiency.
Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin should not be used to treat megaloblastic anaemia of pregnancy. Cyanocobalamin should not be administered before pernicious anaemia or folic acid deficiency has been ruled out.
Must not be administered intravenously.
DOSAGE AND DIRECTIONS FOR USE:
In the absence of neurological involvement, cyanocobalamin may be administered in doses of 250 to 1000 micrograms intramuscularly on alternate days for 1 to 2 weeks, then 250 micrograms weekly until the blood count returns to normal. Maintenance doses of 1000 micrograms are administered monthly.
If there is neurological involvement, cyanocobalamin may be given in doses of 1000 micrograms on alternate days and continued for as long as improvement occurs.
For the prophylaxis of anaemia associated with vitamin B12 deficiency resulting from gastrectomy or malabsorption syndromes cyanocobalamin may be given in doses of 250 to 1000 micrograms intramuscularly each month.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Allergic reactions have been reported after injection.
Vitamin B12 should be given prophylactically only when there is a reasonable indication. Dietary deficiency in the strict vegetarian, the predictable malabsorption of vitamin B12 in patients who have had a gastrectomy, and certain diseases of the small intestine constitute such indications.
Protect from light. Store below 25°C.
Keep out of reach of children.