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|Product Name:||Artemether Lumefantrin Tablets||Composition:||Each Tablet Contains:Artemether 20MG Lumefantrin 120MG|
|Indications:||Treat Certain Kinds Of Malaria Infections||Storage Instructions:||Store Below 30°C. Protect From Light.|
|Expiration Date:||3 Years|
anti malaria tablet,
Artemether Lumefantrin Tablets 20MG+120MG 40MG+240MG 3*4's / Box 3*8's / Box
ARTEMETHER + LUMEFANTRIN TABLETS Antimalarial 20MG+120MG
The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections. Artemether and lumefantrine should not be used to prevent malaria. Artemether and lumefantrine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.
Each 20/120 tablets contains Artemether 20mg, Lumefantrine 120mg.
Each 40/240 tablets contains Artemether 40mg, Lumefantrine 240mg.
Each 80/480 tablets contains Artemether 80mg, Lumefantrine 480mg.
Excipients include Microcrystalline Cellulose, Maize Starch, Polysorbate 80, Purified Talc, Cross-linked sodium carboxy-methylcellulose, Magnesium Stearate.
Both components of tablets have their own action site in the malarial parasite. The presence of the endoperioxide bridge in Artemether (generating singlet oxygen and free radicals: those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity. Morphological changes of the parasitic membranes induced by Artemether have been described, being the result of free-radical action.
Lumefantrine interferes more in the polymerization processes.
Other in vitro tests suggest that both cause a marked diminution of nucleic acid synthesis. Inhibition of protein synthesis as the basic mechanism of action is suggested in studies which showed morphological changes in ribosomes as well as in the endoplasmic reticulum. Although Artemether acts essentially as a blood schizonticide, tablets did clear gametocytes in comparative clinical trials.
Tablet is indicated for the treatment of malaria in children, caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. Falciparum.
Sensitivity to cimetidine or related agents.
Should not be administered to pregnant or lactating patients.
DOSAGE AND DIRECTIONS FOR USE:
Route of Administration: Oral taken
In general: 4mg Artemether/kg body weight in combination with Lumefantrine per day. This dose should be maintained during three consecutives days in order to avoid recrudescence.
Use under physician’s direction.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
With Artemether virtually no side effects have been seen. Laboratory abnormalities such as a slight rise in transaminases and a decrease in reticulocyte count are rare and transient. A lowering of sinus frequency without causing ECG changes has been noticed. At high doses transient abdominal pain, tinnitus and diarrhea have been described but a causal relationship is unclear.
Some antimalarials as halofantrine and quinine can influence the ECG pattern. Attention should be made to patients previously treated with those antimalarials. A reasonable period should be taken in account before to start a. treatment with lumefantrine combinations. For those patients physicians will be prescribed Artemismin derivatives in mono therapy in cause of severe paludism. Sometimes it could be possible that the following common side effect occur; rash, check this with you doctor. Other common side effects may occur as trouble of sleeping, nausea, vomiting, diarrhea, coughing. They need medical attention when persisting.
Store below 30°C. Protect from light, out of reach of children.