Payment & Shipping Terms:
|Product Name:||Indomethacin Capsule||Composition:||Each Capsule Contains:Indomethacin 25MG|
|Indications:||Relieve The Painful Symptoms Of Ankylosing Spondylitits And Osteoarthritis||Urogenital Trichomoniasis,Amoebiasis,Ulcerative Gingivitis, Infections Caused By Anaerobic Bacteria,:||Store In A Dry Place Below 25°C. Protect From Light.|
|Expiration Date:||3 Years|
INDOMETHACIN 25 MG Capsules
Each capsule contains 25 mg indomethacin.
Indomethacin has analgesic, anti-inflammatory and antipyretic properties and inhibits the biosynthesis of prostaglandins:
This action may be the basis of its anti-inflammatory and anti-pyretic properties (and certain of its other effects). It inhibits motility of polymorphonuclear leucocytes and in supratherapeutic concentrations uncouples oxidative phosphorylation in cartilaginous and hepatic mitochondria.
Indomethacin is used to relieve the painful symptoms of ankylosing spondylitits and osteoarthritis, and to relieve the pain and swelling in gout, rheumatoid arthritis, and acute musculoskeletal disorders.
Indomethacin should not be used in pregnant women, children, or patients with psychiatric disorders, epilepsy, or Parkinsonism. It also contra-indicated in individuals with renal disease or ulcerative lesions of the stomach
Contra-indicated in persons hypersensitive to indomethacin, other non-steroidal anti-inflammatory agents, or aspirin, nursing mothers and in patients with bleeding disorders, active peptic ulcer, gastritis, regional enteritis and ulcerative colitis. ACUFLEX may cause dizziness, therefore, patients should be cautioned about engaging in activities requiring mental alertness and motor co-ordination, such as driving a car and operating machinery.
Serious interactions have been reported after the use of high doses of methotrexate with indomethacin. The combined use of indomethacin and diflunisal has been associated with fatal gastro-intestinal haemorrhage. Therefore indomethacin and diflunisal should not be used concomitantly.
DOSAGE AND DIRECTIONS FOR USE:
IT IS RECOMMENDED THAT INDOMETHACIN CAPSULES BE TAKEN WITH FOOD, MILK OR ANTACIDS.
In rheumatic disorders the usual initial dosage is 25 mg twice or thrice daily, increased, if required, up to 150 mg in divided dosis. In acute peri-articular disorders and in low back pain 50 mg may be given twice or thrice daily for about 10 days. In acute gout 50 mg may be given three or four times a day. Total daily dose should not generally exceed 200 mg.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
The most frequent central nervous system effect is severe frontal headache. Dizziness, vertigo, lightheadedness, and mental confusion are frequent. Severe psychosis, hallucinations, and suicide have been reported. Corneal opacities, visual-field changes, and pallor of the optic disk have also occurred. Anorexia, nausea and vomiting, dyspepsia, and diarrhoea may occur. Peptic ulceration, possibly with gastro-intestinal haemorrhage may also occur and is not always preceded by dyspepsia; there may be oesophageal ulceration.
Store in a dry place below 25°C.
Protect from light.
KEEP OUT OF REACH OF CHILDREN