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Hydrocortisone Sodium Succinate Injection Medicines 100MG 1*10VIALS/BOX

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Hydrocortisone Sodium Succinate Injection Medicines 100MG 1*10VIALS/BOX

China Hydrocortisone Sodium Succinate Injection Medicines 100MG 1*10VIALS/BOX supplier

Large Image :  Hydrocortisone Sodium Succinate Injection Medicines 100MG 1*10VIALS/BOX

Product Details:

Place of Origin: China
Brand Name: ZMC/SENA
Certification: GMP
Model Number: 100MG

Payment & Shipping Terms:

Minimum Order Quantity: 100,000 vials
Price: Negotiation
Packaging Details: 1*10VIALS/BOX*100/CATON
Delivery Time: Negotiation
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: 5,000,000 vials per month
Detailed Product Description
Product Name: Hydrocortisone Sodium Injection Composition: Each Vial Contains:100 Mg Hydrocortisone As Sodium Succinate
Standard: BP Package: 1*10VIALS/BOX*100/CATON
Indications: Relief Of Inflammatory Conditions,treatment Of Adrenal Insufficiency States Storage Instructions: Store Below 25°C, Protected From Moisture.
Expiration Date: 3 Years

 

HYDROCORTISONE SODIUM SUCCINATE INJECTION 100 mg

 

COMPOSITION:

Each vial contains: hydrocortisone sodium succinate equivalent to hydrocortisone 100.0 mg 

 

PHARMACOLOGICAL ACTION:

Hydrocortisone sodium succinate acts by controlling the rate of protein synthesis. It forms a steroid-receptor complex with receptor proteins, moves into the nucleus where it binds the chromatin and thus directs the genetic apparatus to transcribe RNA. It also delays the mineralocorticoid activity.

 

INDICATIONS:

As substitution therapy in the treatment of adrenal insufficiency states, where high levels of hydrocortisone are required rapidly.
In patients with known or suspected adrenal insufficiency prior to surgery, or if shock, severe trauma or other stress conditions occur. 
Hydrocortisone sodium succinate is also used for the symptomatic relief of inflammatory conditions and as an immunosuppressant

 

CONTRA-INDICATIONS:

Hypersensitivity to corticosteroids. Tuberculosis. Ocular herpes simplex. Primary glaucoma. Acute psychosis and psychoneurosis. Systemic infection. Peptic ulcer. Osteoporosis.

 

WARNINGS:

Hydrocortisone sodium succinate injection should not be administered intrathecally or subconjunctivally. Toxic effects may result from withdrawal or from continued use of large doses. Hydrocortisone sodium succinate should be given with extreme caution in the presence of congestive heart failure, hypertension in patients with diabetes mellitus, chronic renal failure, uraemia and in elderly patients.

 

DOSAGE AND DIRECTIONS FOR USE:

Hydrocortisone sodium succinate is administered intravenously, intramuscularly or by intravenous infusion. The dose is 100 to 500 mg Hydrocortisone succinate given 3 to 4 times in 24 hours, dosage depending on the severity of the condition and the response.
Children up to 1 year may be given 25 mg, 1 to 5 years –50 mg and 6 to 12 years –100 mg.
Hydrocortisone sodium succinate may be administered in conjunction with suitable intravenous solutions, eg. Dextrose 5% and Sodium Chloride 0,9%, by intravenous infusion, in the desired volume of solution.
If reconstituted with the diluent provided, the solution is stable for 3 days.
The addition of Hydrocortisone sodium succinate to the solution for intravenous use should be made at the time of administration.

Hydrocortisone Sodium Succinate Injection Medicines 100MG 1*10VIALS/BOX

 

SIDE EFFECTS AND SPECIAL PRECAUTIONS:

Hydrocortisone sodium succinate may cause electrolyte disturbances, characterized by hypertension and oedema due to the retention of sodium and water and the increase in potassium excretion. Increased potassium excretion may cause hypokalaemic alkalosis. Increased susceptibility to infection (e.g. sepsis, fungal and viral) and delayed wound healing. Cardiac failure. Peptic ulcerations with haemorrhage and perforation. Glycosuria. Osteoporosis and spontaneous fractures. Increased appetite. Posterior subcapsular cataract. Atrophy of the adrenal cortex and acute adrenal insufficiency during prolonged treatment. Inhibition or arrest of growth in children. Cushing syndrome. Amenorrhoea. Behavioural disturbances, including mental and neurological disturbances. Intracranial hypertension. Thrombo-embolic complications. Lymphocytopaenia. Myopathy. Hyperglycaemia with accentuation or precipitation of the diabetic state. Insulin requirements of diabetic patients are increased. Infections may be masked by anti-inflammatory properties of Hydrocortisone sodium succinate. Hyperhydrosis and aseptic necrosis of bone may occur. Live vaccines should not be given to patients receiving high doses of Hydrocortisone sodium succinate. Patients receiving long courses of Hydrocortisone sodium succinate should be regularly checked for hypertension, glycosuria, hypokalaemia, gastric discomfort and mental changes. Sodium intake may have to be reduced and potassium supplements administered. Daily mass records may indicate fluid retention and back pain may signify osteoporosis. 

 

STORAGE INSTRUCTIONS: 

Store below 25°C.
Protect from light.
Keep out of reach of children.

 

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