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|Product Name:||Benzathine Benzylpenicilline For Injection||Composition:||Each Vial Contains:containing 2.4 M Units Benzathine Penicillin G|
|Indications:||For The Treatment Of Infections Caused By Organisms Sensitive To Penicillin G.||Storage Instructions:||Store Below 25°C, Protected From Moisture.|
|Expiration Date:||3 Years|
Benzathine Benzylpenicilline For Injection 2.4M
When reconstituted with 6 mL water for injection the contents of each vial provides 8 mL containing 2,4 m units Benzathine penicillin G with 0,45% m/m methylparaben and 0,053 % m/m propylparaben as preservatives.
Penicillin inhibits, in susceptible bacteria, the synthesis of peptidoglycan, a complex macromolecule which forms one layer of the cell wall of both gram-positive and gram-negative micro-organisms. Peptidoglycan provides rigid mechanical stability by virtue of its highly cross-linked latticework structure. Deprived of its rigid cell wall, the bacterial cell loses the protection it requires because of its high intracellular osmotic pressure. Lysis of the cell membrane and death follows.
Benzathine penicillin G is slowly absorbed from intramuscular depots and produces the longest duration of detectable antibiotic of all the available repository penicillins.
For the treatment of infections caused by organisms sensitive to penicillin G.
Hypersensitivity to penicillin.
DOSAGE AND DIRECTIONS FOR USE:
Treatment of streptococcal infections:
A single dose of 600 000 to 900 000 units for children and 900 000 to 1200 000 units for adults is recommended. If necessary, the dose may be repeated as required.
Treatment of susceptible staphylococcal infections:
Administer 1200 000 units and repeat in 48 to 72 hours if required.
Treatment of pneumococcal infections (except pneumococcal meningitis):
One dose of 600 000 units, repeated in 24 hours suffices for mild or moderate cases.
In severe infections, this dose should be repeated every other day until the temperature has been normal for 48 hours.
Treatment of secondary bacterial infections:
In many viral infections an injection of 600 000 units is useful in the treatment of complications from secondary bacterial infections.
Treatment of gonorrhoea:
One dose of 600 000 to 1 200 000 units is usually effective.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
In rare instances the injection of penicillin may cause acute anaphylaxis which may prove fatal unless promptly controlled. This type of reaction appears more frequently in patients with previous sensitivity reactions to penicillin, and in those with bronchial asthma or other allergies. Resuscitative medicines such as adrenaline, aminophylline and pressor amines should be readily available for emergency administration.
Other hypersensitivity reactions which may occur are: skin rashes, contact dermatitis, oral lesions, fever, eosinophilia, interstitial nephritis, angioedema serum sickness and the Arthus phenomenon. Care should be taken to avoid accidental intravenous or intra-arterial administration.
Store in a cool (below 25°C) place.
Keep out of reach of children.
Administer suspension within 24 hours after reconstitution.
Discard any unused portion.