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|Product Name:||Aciclovir Tablets||Composition:||Each Tablet Contains:Aciclovir 400MG|
|Indications:||Recurrent Herpes Simplex Infections,recurrent Herpes Genitalis,Herpes Zoster Infections||Storage Instructions:||Store Below 25°C, Protected From Moisture.|
|Expiration Date:||3 Years|
Aciclovir Tablets 400MG
Each tablet contains Aciclovir 400 mg.
|-||Treatment of initial and recurrent Herpes simplex infections of the skin and mucous membranes.|
|-||Treatment of initial and recurrent Herpes genitalis infections in immunocompromised and non-immunocompromised patients.|
|-||Prophylaxis of Herpes simplex infections in immunocompromised patients.|
|-||Prophylaxis against recurrent (>6 episodes per year) Herpes genitalis infections in HIV-infected patients and patients receiving cancer chemotherapy or immunosuppressive therapy.|
|-||Treatment and prophylaxis of Herpes zoster infections including treatment of Herpes zoster ophthalmicus. Treatment is effective if started within 48 hours of onset of rash.|
|-||Treatment of chicken pox especially in those at increased risk of severe infection or complications such as children over 12 months of age with a chronic cutaneous or pulmonary disorder, or children receiving corticosteroids. Oral aciclovir is effective in the treatment of varicella zoster infections if started within 24 hours of onset of rash.|
Aciclovir is contra-indicated in patients hypersensitive to aciclovir or ganciclovir. In patients with pre-existing impairment of renal function, neurological abnormalities or dehydration, the potential risks and benefit should be carefully considered. The safety in pregnancy and lactation has not been established.
Impairment of renal function can occur in patients on aciclovir therapy.
DOSAGE AND DIRECTIONS FOR USE
Usual Adult Dose
Genital Herpes infections
Initial infection: 200 mg orally, five times a day for ten days.
Recurrent infections: 200 mg orally, five times a day for five days.
Chronic suppressive therapy (for prophylaxis against recurrent genital Herpes): 400 mg orally, twice a day or 200 mg orally, three to five times a day.
Herpes Zoster: 800 mg orally, five times a day for seven to ten days.
Varicella (treatment): 800 mg orally, four times a day for five days.
To be started within 24 hours of onset of rash
Directions for use:
Aciclovir tablets may be taken with meals since absorption has not been shown to be significantly affected by food. As it may take longer for lesions of Herpes simplex to heal in immunocompromised patients, the duration of therapy may need to be prolonged beyond the recommended period until the lesions are crusted over or epithelialized. The tablets must be dispersed in 50 mL of water or swallowed whole.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
Adverse effects reported include gastrointestinal disturbances and headache.
Alteration in values of bilirubin and liver related enzymes, blood urea and creatinine & megaloblastic haemopoiesis has also been reported in patients receiving aciclovir.
Patients allergic to ganciclovir may also be allergic to aciclovir.
Aciclovir should be administered with caution to patients with renal impairment and doses should be adjusted according to creatinine clearance.
No unusual toxicity has been observed in studies done in children using doses up to 80 mg/kg/day. In children older than 2 years of age the pharmacokinetics of aciclovir is similar to that seen in adults with normal renal function.
Due to age related decrease in renal function, geriatric patients may require adjustment of dosage.
Store below 25°C, protected from moisture.
KEEP OUT OF REACH OF CHILDREN